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We computed annual percentage change (APC) and average annual percentage changes (AAPC) to summarize the rate of change during the entire study period and during segments of the study period where points of inflection occurred

Importantly, stimulation of nAChRs in dopaminergic neurons of the VTA of the midbrain and in the shell of the NA are critical in drug-induced reward pathways that are important for the perception of pleasure and reward (Figure 4) [25]

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