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they cannot be achieved on a product-by-product basis. The company must request authorization from the FDA to continue the special marketing of the cigarettes after the current order expires in five years
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As DNA methylation is mainly catalyzed by DNA methyltransferases (DNMTs), researchers found that DNMT1 expression was significantly higher in the lung tissues of the smokers compared to the expression in the nonsmokers [27]

The results of the study were published in todays New England Journal of Medicine
