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Two factors drove the long slide in demand: the 1964 Surgeon General's report linking cigarettes to lung cancer, and the 1998 Master Settlement Agreement, which curbed marketing and raised cigarette prices

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Tobacco brands offering organic, additive-free, or aromatic variants have captured growing interest, particularly from users who seek customization and a more authentic tobacco profile

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Impact of Smoking on Male Reproductive Health While smoking has been associated with increased testosterone levels in some studies, it has also been linked to lower testosterone levels in men

We performed gene function annotation analysis of the 31,572 unigenes