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Hence, it seems reasonable that UDCA was found to be associated with suppressor of HCC, because UDCA can ameliorate insulin sensitivity and liver inflammation by stabilizing the p53/MDM2 interaction and enhancing MDM2-dependent ubiquitination of p53 138

Figure 2.7 Strands of DNA form genes

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The development of GEMMs has allowed for insights into the biology of p53 mutant cancers, as they reliably mimic the oncogenic mutations underpinning cancer formation in humans and hence enable the study of the impact of specific oncogenic driver events

August 5, 2000