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E-cigarettes contain extremely high concentrations of nicotine and are known to be harmful in other ways, especially to young children

showed that nicotine could enhance HLA-DR expression, costimulatory molecules (CD86 and CD40), and adhesion molecules (LFA-1 and its ligand, CD54) in human DCs

Thun MJ, Apicella LF, Henley SJ

Some countries allow packs of more or fewer than 20 cigarettes, while others restrict packaging to specific standard sizes

Canada has strict regulations governing online tobacco sales to protect minors and ensure compliance with federal and provincial laws

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