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Cochrane Database of Systematic Reviews, titled Nicotine receptor partial agonists for smoking cessation, indicates that Varenicline increases the likelihood of quitting smoking by about 60% compared to placebo

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Although it may seem counterintuitive, some individuals find smoking to be a stress-reliever or a way to cope with anxiety or depression
Psychosom Med

Mol Nutr Food Res 2008;52(1):7-25

When you smoke a cigarette, you inhale an incredibly addictive and toxic substance called nicotine
