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However, complications arising from its misuse or overdose are severe

The most important observation from our study is that the early course of nicotine dependence seems to involve a vicious cycle in which exposure to nicotine through smoking promotes the early development of craving and withdrawal, these symptoms drive an escalation in smoking frequency as tolerance develops, and this escalation promotes the development of additional symptoms of dependence

Colonoscopy is performed by inserting a device called a colonoscope into the anus and advancing through the entire colon

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