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A critical stage in spermatogenesis for radiation-induced cell death in the medaka fish, Oryzias latipes

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The mTOR pathway can be activated by high levels of nutrients and energy, such as a high ATP/ADP ratio, growth factors and oxygen, which promote anabolism and inhibit catabolism [72, 73]

Study participants who switched to mostly THS use showed significantly lower white blood cell counts, 0.475 GI/L and 0.420 GI/L after 3 and 6 months, respectively, compared with continued smoking

However, spontaneous germ cell necrosis takes place very sporadically in the testes of wild type or Tp53-/- mutant mice at 6-8 weeks of age ( Table 1 Several phenotypes associated with spermatogenesis and function caused by Tp53 genomic knockout or overexpression