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In line with this, evidence from the MAM model shows (i) 5 but not 1-3-GABA A receptors are reduced in the subiculum and CA1 [88], (ii) overexpression of the 5, but not 1, subunit normalizes hippocampal hyperactivity [32], and (iii) an 5-GABA A PAM was able to normalize hippocampal hyperactivity [34] and attenuate VTA dopaminergic firing to a greater extent than the non-specific benzodiazepine midazolam [33]

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E-cigs might be the most promising product for tobacco harm reduction to date, because, besides delivering nicotine vapour without the combustion products that are responsible for nearly all of smokings damaging effect, they also replace some of the rituals associated with smoking behaviour

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