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PMID 10571595

Worry no more

& Brenner, D
the 2013 review suggests that the lower limit causing fatal outcomes is 5001000 mg of ingested nicotine, corresponding to 6.513 mg/kg orally
16 March 1997
Nicotine replacement therapy (NRT): Although co-administration of varenicline (1 mg twice daily) and transdermal nicotine (21 mg/day) for up to 12 days did not affect nicotine pharmacokinetics, the incidence of adverse reactions was greater for the combination than for NRT alone [see DRUG INTERACTIONS ]
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