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Lower plasma levels in smokers have also been documented for the following pharmaceuticals: mirtazapine, amitriptyline, escitalopram [62], and venlafaxine [56]

Their choice to continue doing so is completely out of free will

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Increased Risk of Cancer: Smoking is a leading cause of various types of cancer, including lung, throat, mouth, and esophageal cancer

In addition, the estimated seizure incidence increases almost tenfold between 450 and 600 mg/day

While you might still be in ketosis, the rate at which your body can oxidize fat is significantly slowed down because you are essentially choking your metabolic engine
