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Age-specific mortality rates (per 100000) comparing 1990 and 2021 for overall tobacco exposure (D), smoking (E), and secondhand smoke exposure (F) Local drift, age, period, and cohort effects on tobacco-related lung cancer burden in the Western Pacific Region The age-period-cohort model assessed the trends in mortality and DALYs of tobacco-attributable lung cancer from four aspects: local drift, age effect, period effect, and cohort effect