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To investigate the effect of flavor, the disposable e-cigarette was included in two study arms, one using a fruit flavor and the other using a tobacco flavor

There are still different categories of cigarette packaging, such as packs containing 10 cigarettes, 20 cigarettes, and larger packages for heavier smokers

Another report shows a significantly higher PRM1/PRM2 ratio in heavy smokers that was closely linked to anomalies in histone-to-protamine transfer and changed protamine mRNA expression in human sperm [101]

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