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During Phase I, it undergoes microsomal oxidation [] and produces various metabolites such as cotinine, nornicotine, demethyl cotinine, trans-3-hydroxy-cotinine, and d-(3-pyridyl)--methylaminobutyric acid. [,] In Phase II, the metabolites undergo N- and O-glucuronidation and then get excreted through urine, faces, bile, saliva, sweat, and other routes

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