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In a large cohort of active young men, dual users demonstrated significantly poorer performance in cardiorespiratory endurance and muscular fitness tests compared to never users, including slower 2-mile run times and fewer push-ups and sit-ups performed, even after adjusting for physical training habits (82)

Archived from the original on July 3, 2011

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Many characteristics of these trials, such as short durations, confined settings and choice of comparators and participants, are not representative of real-world use and fail to adequately investigate whether HTPs reduce harm and are beneficial to public health. The authors overall conclusion is that: The conduct and reporting of HTP interventional clinical trials were poor in many respects and limited to investigating effects of short-term exposure