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Less sensitive neurotransmitter receptors : Nicotine typically interacts with neurotransmitters like dopamine and acetylcholine, and chronic use can desensitize them over time

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Ebbert JO, Dale LC, Severson H, et al

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After an individual smokes a cigarette some of the effects that can be immediately felt include: Increased alertness Feelings of relaxation Mild euphoria Bad breathe Decreased appetite Dizziness Increased blood pressure and heart rate Nausea Headache Decreased skin temperature Coughing Long-Term Effects of Cigarette Addiction Even though nicotine can be as addictive as drugs like heroin, or methamphetamine, hardly anyone would argue that cigarette smoking has more negative consequences than shooting up

The smoke can stay thick and consistent with proper setup and heat management