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The mRNA and protein levels of both mtTFA and cytochrome c oxidase subunit II (COX II) were significantly decreased, but the group of mice treated with 5-aza-2-deoxycytidine (AZA, a DNA methyltransferase inhibitor) had restoration of the above changes which suggesting that the removal of DNA methylation by AZA can protect against CSE-induced cell apoptosis

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29 Snuff use leads to higher accumulated nicotine levels and a more continuous exposure on the nicotine receptors, compared with short, intermittent exposure in smoking, which may explain differences between effects of smoking and snuff use