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Liraglutide treatment reduced neuroinflammation and ameliorated ER stress in the inferior olive of the aged Wolfram syndrome rat model.70 Moreover, it can prevent the disease before the appearance of metabolic symptoms.71 Liraglutide may engage Akt and signal transducer and activator of transcription 3 signaling to favor adaptive responses and shift cell fate from apoptosis to survival under chronic ER stress conditions in nerve cells.72 Our team used palmitic acid stimulation to induce neuronal IR, confirming that ER stress is involved in the functional damage of neurons induced by IR, and exendin significantly alleviates both ER stress and neuronal damage (data not shown)

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