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Hers and Hims now offer access to GLP-1 medications like semaglutide and tirzepatide to help with weight loss

Kumarathurai P, Anholm C, Fabricius-Bjerre A, et al

Furthermore, studies using a peripherally administered exenatide analogue conjugated to vitamin B12, which is sterically hindered from accessing regions protected by the blood brain barrier, improves glucose control in comparable fashion to unmodified exenatide, presumably at the level of the -cell, but does not induce emesis in the house musk shrew ( Suncus murinus) or rats (78, 79)

doi: 10.1016/j.ijcard.2020.06.011 105 CahnAWiviottSDMosenzonOMurphySAGoodrichELYanuvIet al

doi: (Of importance) This cross-sectional study provides direct evidence that GLP-1 receptor agonist use may be accompanied by reduced intake of protein and selected micronutrients

Unlike many current weight-loss drugs that focus mainly on GLP-1 activity, retatrutide targets three hormone pathways: GIP, GLP-1, and glucagon