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In the GLP-1 RA group, 33 participants were subsequently newly diagnosed with heart failure, compared with 15 in the SGLT2i group (RR 0.44 [95% CI 0.23, 0.83] p =0.0092)

It can take several months to see the full effects of semaglutide because treatment is started at a lower dose and then gradually increased to lessen side effects like nausea and diarrhea

When those five pieces line up, the chart makes sense

Even mild dehydration (2 percent of body weight) can reduce exercise performance by 10 to 20 percent and significantly delay recovery

For individuals coping with obesity, even modest gains in these markers can translate into significant decreases in long-term cardiovascular risk

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