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The first reported GLP-1/GIP co-agonists, which had prolonged half-lives due to the use of fatty acylation or PEGylation, yielded synergistic effects, lowering body weight in obese rodents relative to the individual mono-agonist comparators [465] and having a greater insulinotropic effect in non-human primates

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La comprensin de su mecanismo de accin es fundamental para evaluar sus efectos potenciales en diferentes sistemas del cuerpo, incluido el sistema inmunolgico

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Water and salt metabolism can regulate blood-volume by affecting plasma crystal osmotic pressure

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E.SchneiderL

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