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[15] However, subsequent analysis revealed important context: the increased risk was predominantly observed in patients with pre-existing diabetic retinopathy and those who experienced rapid improvements in glycaemic control

Because the review of 48 studies, although comprehensive, looked at a wide and diverse group of people -- from those with conditions such as diabetes and kidney disease, and those with different starting and end points and who took different medications -- the conclusions drawn also highlight its limitations

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Role of GLP-1 Agonists and SGLT-2 on Diabetes and Kidney Disease Post Liver Transplant The emergence of Glucagon-like peptide-1 receptor (GLP-1) agonists and Sodium-glucose cotransporter-2 (SGLT-2) inhibitors as glucose-lowering therapies has opened new therapeutic avenues for managing patients with diabetic kidney disease

He had some success with semaglutide (prescribed as Ozempic and Wegovy) but wanted to level up to the even more powerful tirzepatide

With only 338 participants, a cardiovascular event rate of even 1 to 2% could easily be missed statistically