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Coverage varies across the entire class of GLP-1 receptor agonists, with diabetes indications typically covered but obesity indications excluded in most states

Many insurers may impose step therapy requirements, favoring other GLP-1 RAs before approving tirzepatide

Accessed January 2026

Undereating despite appetite suppression poses real risks: fatigue, dizziness, hair loss, and hormonal disruption can occur at extreme deficits below 1,200 calories daily

The agency said patients also should avoid buying the drugs from unfamiliar sources

Hepatitis B infection as a possible cause of focal segmental glomerulosclerosis (FSGS)