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doi: 10.3748/wjg.v31.i37.110797 14 TourkochristouEAssimakopoulosSFThomopoulosKMarangosMTriantosC

Mutations in the FTO gene (rs9939609) and MC4R gene (rs17782313) are linked to stronger hunger drive and slower metabolic adaptation, meaning carriers may experience faster, more pronounced weight regain

The growing body of evidence linking obesity to at least 13 types of cancer, cardiovascular disease, sleep apnea, osteoarthritis, and non-alcoholic fatty liver disease has elevated obesity from a cosmetic concern to a recognized chronic disease requiring pharmaceutical intervention, fundamentally shifting payer willingness to reimburse GLP-1 therapies

Dietary changes Eat smaller, more frequent meals instead of large ones

Whether the same effect would show up in a generally healthy person trying to lose weight is an open question

When evaluating any GLP-1 provider, confirm they source from licensed 503A pharmacies