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Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study

Instead, it has been studied primarily for its potential role in regulating fat metabolism

Genetics, appetite regulation, metabolism, fat storage, energy expenditure, GLP-1, GIP, leptin, ghrelin, and insulin may influence weight regulation

These medications have become some of the most effective medications to improve blood sugar, reduce the risk of certain cardiovascular conditions, and lose weight out there, with people losing up to 15% to 21% of their bodyweight on average in a little more than a year

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But is this combination truly effective, or could it pose risks