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Clinically, this matters because chronic migraine is not defined by one dramatic headache

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The STEP UP trial, published in The Lancet Diabetes & Endocrinology in September 2025, showed 18.7% average weight loss at 72 weeks compared to 15.6% at the standard 2.4 mg dose
This translates to a difference of 6.5% in mean weight decrease, compared with 20.2% for those receiving semaglutide, a 14% weight decrease

GLP-1 medications reduce food intake, which means less fiber and less water from food