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Separately, a significant interaction effect of GLP-1 RAs and CNQX, an AMPA/kainate receptor antagonist, co-treatment was observed on food intake 3, 6, and 24 hours post-treatment (all ANOVAs F 1,21 4.89, p 0.04).Reference Mietlicki-Baase, Ortinski and Rupprecht 36 , Reference Mietlicki-Baase, Ortinski and Reiner 37 Moreover, the foregoing trend indicates that antagonism of AMPA/kainate receptors significantly attenuates food intake suppression effects associated with GLP-1 RA treatment.Reference Gateva, Hristov and Ivanova 26 , Reference Mietlicki-Baase, Ortinski and Reiner 37 The food suppressive effects were attributed to decreased meal size (F 1,21 6.11, p 0.03) and minimally on meal frequency (F 1,21 4.46, p 0.05).Reference Mietlicki-Baase, Ortinski and Rupprecht 36 When the rats were co-treated with GLP-1 RA and MK-801, GLP-1 RA-induced suppression of food intake was not affected