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The widespread acceptance of metformin evolved after the realization that lactic acidosis was not a major problem in individuals with normal renal function
It is too early to conclude if the slowing growth is a temporary pause as patients evaluate these new drug therapies or if it's a trend that continues. -Intuitive Surgical, July 2023 (Q223 earnings call) Markets rapidly woke up to the new reality

And the two are not always mutually exclusive

Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression
The NCI analyzed several studies to observe physical activitys impact on overall cancer risk

GLP-1 RA use was associated with an overall lower risk of death from any cause over a 10-year follow-up period among breast cancer patients