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doi:10.1016/j.annonc.2026.04.013

Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes

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In conclusion, GLP-1R signals exclusively via G s proteins (G s selective) and does not undergo significant desensitization, in contrast to GIPR that interacts with both G s proteins and arrestins equally robustly (non-selective, pleiotropic balanced receptor) and is severely desensitized in vivo

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Published research on the named ingredients involves oral supplementation