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Department of Health and Human Services Physical Activity Guidelines recommend at least 150-300 minutes of moderate-intensity aerobic activity weekly, along with muscle-strengthening activities on 2 or more days per week

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The link between GLP-1 and the heart also highlights the link between dementia and cardiometabolic disease, whereby risk reduction can pose as an additional effective mechanism in the treatment of AD [41]

A systematic review and meta-analysis of supervised-exercise training interventions in children and adolescents showed that both aerobic and resistance exercise, at vigorous or moderate-to-vigorous intensities, with a volume of 60 min/session and a frequency of 3 sessions/week, aiming to improve cardiorespiratory fitness and muscular strength had benefits on hepatic fat content reduction in youth [122]

These findings are important as they may broaden the indications for these medications and benefit a larger patient population, added Mir Ali, MD, a general surgeon and bariatric surgeon as well as the medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA
