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GH overdose can impair insulin sensitivity, leading to insulin resistance and hyperglycemia in adults, attributed to GHs antagonistic effects on insulin in the liver and other tissues [262,263,264]

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This is why Canadas 2025 obesity guidelines and most clinicians treat them as first-line for many patients seeking weight loss treatment

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So is depression , which sometimes becomes more apparent when the comfort of eating is no longer available as a coping mechanism