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For most affected participants, the symptoms were manageable and did not lead to treatment discontinuation, but it represents a novel consideration that researchers should be aware of

More common side effects include nausea/vomiting and pancreatitis

In a controlled crossover feeding study, a high-GI meal selectively increased activation in reward and craving regions four hours postprandially compared with an isocaloric low-GI meal, independent of palatability [26]

Research shows that dual activation of these pathways may lead to better overall metabolic health outcomes than either pathway alone

Additionally, parenteral GLP-1 treatments have strong clinical validation, which increases physician confidence and patient adherence, further driving market dominance

in the raw-efficacy dimension, it is competitive rather than clearly superior, and remains investigational