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The proposed mechanism of action of these peptides is that they enter the hind-brain from the peripheral bloodstream, and interact directly with GLP-1 receptors in the brain - possibly the parabrachial nucleus ( 2 Materials and methods 2.1 Materials Peptides exendin-4 (exenatide) and semaglutide were obtained from Bachem AG, Bubendorf, Switzerland

Importantly, glucagon is rapidly inactivated in the circulation by enzymes, including DPP-4, to generate inactive glucagon (48)

Its a different molecule with a different manufacturing supply chain, and its patents wont expire until 2031+ either

Zhang Z, Zhang Q, Tan Y, et al

1 2 Pharmaceutical Capsules

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