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Glycemic Safety Of particular importance given the glucagon receptor agonism component of retatrutide, there were no clinically significant increases in blood glucose or concerning hyperglycemic events despite glucagon's classical glucose-raising effects - confirming that the GLP-1 component successfully counteracts glucagon's impact on glucose homeostasis

In doing so, we contextualize these findings within broader frameworks of translational neuropsychopharmacology and systems biology

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doi: 10.1111/mmi.12859

They stimulate insulin secretion, suppress glucagon release, and slow gastric emptying

This stimulation can lead to undesirable side effects such as insomnia, anxiety, and cardiovascular issues, including elevated heart rate and blood pressure