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Retatrutide has been tested at up to 12 mg weekly in Phase 2 and Phase 3 trials

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A secondary analysis by Borlaug et al (2025) showed that tirzepatide reduced markers of circulatory overload, such as NT-proBNP, and improved the left ventricular diastolic function [30]

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If you experience severe abdominal pain that persists for more than a few hours, especially if accompanied by vomiting and fever, you should discontinue Zepbound and seek immediate medical evaluation

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Understanding tirzepatide's mechanism of action is essential for anticipating potential side effects, as many adverse reactions relate directly to its effects on the gastrointestinal system and glucose metabolism

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