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The effect is attributed to KGMs ability to modulate gut microbiota compositionspecifically, increasing the abundance of Akkermansia muciniphila and Alistipes and decreasing the abundance of Allobaculum , Acetatifactor , and Helicobacter pylori accompanied by enhanced SCFA metabolism

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This phase 3 randomized controlled trial enrolled participants with BMI over 24 kg/m (the obesity threshold in Asian populations) or BMI over 28 kg/m with comorbidities

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