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The mechanism that slows gastric emptying, believed to cause gastroparesis, is present in both semaglutide and tirzepatide drugs

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The dosage strengths of injectable semaglutide for weight reduction are 0.25 mg dose pen, 0.5 mg dose pen, 1 mg dose pen, 1.7 mg dose pen, and 2.4 mg dose pen

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Common (Usually Mild to Moderate) These often improve as the body adjusts: Nausea Reduced appetite Feeling full quickly Bloating or indigestion Constipation or diarrhoea Mild fatigue Less Common Side Effects Vomiting Acid reflux or heartburn Dizziness Headaches Changes in bowel habits These may occur if dose escalation is too fast or dietary intake is not adjusted

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A sample size of eight youth would have 80% power to detect a 10% difference in GPR and rate of fractional gluconeogenesis, = 0.05

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