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In CD animals, semaglutide did not affect the weight of fat and lean organs, indicating a specific effect of semaglutide on fat storage during malnutrition

All the participants were required to have had at least one unsuccessful dietary weight-loss effort

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A.YoungA.GillR.AburasaynH.et al (2021)

Pathophysiology of obesity and HFpEF Patients with HFpEF exhibit an increase in overall cardiac volume, and this is more pronounced in obese individuals, manifesting as ventricular dilatation, ventricular wall thickening, and increases in the amount of epicardial adipose tissue (EAT) [24, 25]