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Some conditions create enough additional risk that the combination requires physician supervision at minimum, and in some cases should be avoided entirely

Medications that are FDA-approved for both weight loss and other indications may only be covered by Part D plans for non-weight loss indications

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"Instead, it has remained remarkably robust, raising important questions about how these products are regulated and how patients can know whether they're receiving medications that meet appropriate quality standards." Compounded GLP-1 drugs expanded rapidly during nationwide shortages of Wegovy and Zepbound, when federal regulations temporarily allowed pharmacies to compound copies of medications in short supply