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Alternative medicine

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The time course of muscle mass loss generally parallels the rate of weight loss, with the most rapid changes occurring in the first 34 months of treatment, particularly with higher-dose agents such as semaglutide and tirzepatide

JLS has been on the Speaker Bureau of Abbott, AstraZeneca, Boehringer Ingelheim/Eli Lilly, Janssen, Merck, Novo Nordisk, Salix and Sanofi, has been a Board Member/Advisory Panel for Ascensia Diabetes, Novo Nordisk, and Sanofi

In other words, despite producing significantly greater overall weight loss than semaglutide or tirzepatide, retatrutide did not cause a disproportionately higher percentage of muscle loss (Coskun et al., Lancet Diabetes Endocrinol , 2025)

subcutaneous semaglutide (up to a dose of 2.4 mg weekly), or dual gastric inhibitory polypeptide (GIP)/GLP-1 receptor agonists e.g