glp-1 receptor agonists weight loss Medications: Everything You Need to Know GLP-1 Receptor Agonists at the

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doi: 10.3390/diseases12010014 45 DruckerDJ

Incretin-based therapy in type 2 diabetes: an evidence based systematic review and meta-analysis

Wang, M

SGLT-2 inhibitors act primarily in the renal proximal tubule and have no established direct actions on mesolimbic reward circuits in the brain.63 On the contrary, neurotropism is a distinct property of GLP-1 receptor agonists.62 GLP-1 is produced in the brain, GLP-1 receptors are present in areas of the brain involved in impulse control and reward signalling, and a pharmacologically administered exogenous GLP-1 receptor agonist crosses the blood-brain barrier and enters the brain within minutes, strengthening the inference that the observed GLP-1 receptor agonist anti-addictive properties are likely specific and biologically plausible drug effect of GLP-1 receptor agonism, distinct from the general benefits of treating diabetes that would be expected with both SGLT-2 inhibitors and GLP-1 receptor agonists.6465 These observational findings do not by themselves justify the prescribing of GLP-1 receptor agonists specifically to prevent or treat SUDs