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Semaglutide changes how your brain signals hunger and reward

Udayabagya (Bud) Halim, Waters | Wyatt Technology October 15, 2025

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Introduction This study evaluated the long-term effectiveness of once-weekly subcutaneous semaglutide versus alternative treatment in adults with type 2 diabetes (T2D) in routine clinical practice.Research design and methods The SEmaglutide PRAgmatic (SEPRA) was a 2-year, randomized, open-label, pragmatic clinical trial ( NCT03596450)

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