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Ibuprofen is an anti-inflammatory, meaning it both reduces pain and actively decreases the inflammatory response at the injection site

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Maintaining some level of medication, even at reduced frequency, may help prevent this rebound

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That is, if GLP1 receptors are selectively ablated from proopiomelanocortin neurons, then proopiomelanocortin neurons may still be activated in response to GLP1 receptor agonists, albeit indirectly