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Expanding coverage would make these products more accessible to underserved populations, particularly those disproportionately affected by obesity and diabetes

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However, despite these preclinical observations it is interesting that lixisenatide did not reduce MACEs in the ELIXA trial [53]
These changes were partially moderated by changes in brain morphometry, underscoring the interrelationship between weight and brain structure/ function
In AD mouse models, pathophysiological changes, such as anti-apoptotic effects, reduced A deposition and phosphorylated hippocampal tau, protection from synapse loss, reduced inflammatory and oxidative stress response in the cortex and hippocampus, and increased BDNF have been observed [119,120,121]

Writingoriginal draft preparation: Joya Ghaleb, Katy Kaleen Khouzami, Nicolas Nassif, Philippe Attieh, Mohammad Feras Al Ajlani, and Jana Bou Sleiman
