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In ovariectomy (OVX)-induced osteoporosis in aged rats, exendin-4 enhanced bone strength and prevented exacerbation in trabecular microarchitecture ( The Impact of GLP-1 on Bone Fractures The relationship between GLP-1 and the risk of bone fractures has not been fully elucidated

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Efpeglenatide: The AMPLITUDE-O trial (2021) demonstrated a 27% MACE reduction (HR 0.73, 95% CI 0.580.92) in 4076 T2DM patients, with significant reductions in stroke and HF events [19]

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