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Patients with diabetes should perform home glucose monitoring as directed, with increased frequency during dose adjustments

They were originally developed to treat type 2 diabetes and are now also prescribed for chronic weight management and certain cardiovascular conditions

Potential benefits of using GLP-1 receptor agonists after gastric sleeve surgery include: Enhanced weight loss : Observational studies suggest post-bariatric patients using GLP-1 receptor agonists may achieve additional weight reduction, typically around 510% of body weight, though individual responses vary considerably Improved glycaemic control : Particularly beneficial for patients with type 2 diabetes or prediabetes, as GLP-1 agonists enhance insulin secretion and reduce blood glucose levels Reduced appetite : These medications can help patients who struggle with persistent hunger despite surgical intervention Cardiovascular benefits : Semaglutide has demonstrated cardiovascular risk reduction in people with established cardiovascular disease, which may benefit eligible post-bariatric patients with this specific risk profile Maintenance of weight loss : May help prevent weight regain during the critical maintenance phase Potential risks and considerations include: Gastrointestinal side effects : Nausea, vomiting, diarrhoea, and constipation are common, particularly during dose escalation

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The Clinical Mechanism Behind Semaglutide Weight Loss Semaglutide works by activating GLP-1 receptors in the brain's appetite control centers, reducing hunger signals and increasing satiety

AE-O is supported by the National Institute for Health and Care Research (NIHR) Applied Research Collaboration (ARC) Northwest London