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The safety of weight reduction medications has long been a concern, with numerous drugs being withdrawn from the market owing to safety issues [28,29]

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The connective tissue between this academic proof-of-concept and retatrutide was Eli Lilly's own dual-agonist program, which produced tirzepatide, a GIP/GLP-1 receptor agonist that supplied clinical validation for unimolecular multi-receptor pharmacology