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Non-diabetic patients in these trials experienced benefits beyond weight reduction, including improved cardiovascular markers, better blood pressure control, and reduced inflammation

Translation to clinical benefit will require biomarker-driven studies incorporating fluid and imaging measures of proteostasis

Once-monthly maridebart cafraglutide for the treatment of obesitya phase 2 trial

These assays enable precise functional readouts of receptor activation, offering biologically relevant data that cannot be captured by physicochemical methods alone

B., Berntzen, G., Michaelsen, T
Schirra, J