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In contrast, recommendations for treatment selection in the second-line setting have been outlined in international guidelines, such as the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) guidelines, which inform choice of treatment according to an individuals CV and chronic kidney disease (CKD) risk [15]
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Interestingly, while administration of GEP12 did not result in a reduction in GLP-1R internalization, when evaluated in the presence of a Y1-R antagonist, it elicited increased insulin secretion in rat islets compared to results obtained with either GEP44 or Ex-4
Confounding factors It is important to first note that the majority of articles that were assessed which provided insight into patient demographics reported patients with confounding factors for retained gastric contents and aspiration (Ushakumari and Sladen 2024
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doi: 10.1038/s41586-018-0849-9 59 RosarioWDAlessioD
