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35 Significant advances in pharmacological treatment have primarily focused on HFrEF, the current therapy for which is built on four key pillars: angiotensin receptorneprilysin inhibitor (ARNI) or, alternatively, ACE inhibitors or angiotensin receptor blockers

Deal CL, Tony M, Hoybye C, et al

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doi: 10.1507/endocrj.ej15-0749 29 PerriniSLaviolaLCarreiraMCCignarelliANatalicchioAGiorginoF

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This provides conservative, real-world estimates